Title Associate Professor
Degree PhD
Department Department of Life and Environment Engineering
E-mail mochizuki[ at ]
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Education 2003 BS, Tokyo Institute of Technology
2005 MS, Tokyo Institute of Technology
2008 PhD, Kyushu University
Employment History 2008-2013 Research Associate, The University of Kitakyushu
2014 Research Associate, JST
2015- Associate Professor, The University of Kitakyushu
Research Interest Biomaterial, Drug Delivery System, Molecular Biology

1. Mochizuki S, Nishina K, Fujii S, Sakurai K. The transfection efficiency of calix[4]arene-based lipids: the role of the alkyl chain length. Biomater. Sci., 3(2), 317-322 (2015).

2. Mochizuki S, Morishita H, Adachi Y, Yamaguchi Y, Sakurai K. Binding assay between murine Dectin-1 and b-glucan/DNA complex with quartz-crystal microbalance. Carbohydr. Res., 391, 1-8 (2014).

3. Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc. Natl. Acad. Sci. U.S.A. 111(8), 3086-3091 (2014).

4. Sakashita M, Mochizuki S, Kazuo S. Hepatocyte-targeting gene delivery using a lipoplex composed of galactose-modified aromatic lipid synthesized with click chemistry. Bioorg. Med. Chem., 22(19), 5212-5219 (2014).

5. Mochizuki S, Morishita H, Sakurai K. Macrophage specific delivery of TNF-a siRNA complexed with b-1,3-glucan inhibits LPS-induced cytokine production in a murine acute hepatitis model. Bioorg. Med. Chem., 21(9), 2535-2542 (2013).

6. Mochizuki S, Higuchi S, Sakurai K. ssDNA–dsRNAs are cleaved at the next to its chimera- junction point by an unknown RNase activity. Biochem. Biophys. Res. Commun., 428(4), 433-437 (2012).

7. Mochizuki S, Kanegae N, Nishina K, Kamikawa Y, Koiwai K, Masunaga H, Sakurai K. The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine. Biochim. Biophys. Acta.1828(2), 412- 418 (2012).

8. Mochizuki S, Sakurai K. Dectin-1 targeting delivery of TNF-a antisense ODNs complexed with b-1,3-glucan protects mice from LPS-induced hepatitis. J. Control. Release, 151(2), 155-61 (2011).

9. Mochizuki S, Sakurai K. b-1,3-glucan/antisense oligonucleotide complex stabilized with phosphorothioation and its gene suppression. Bioorg. Chem., 38(6), 260-264 (2010).

10. Mochizuki S, Kano A, Shimada N, Maruyama A. Uptake of enzymatically-digested hyaluronan by liver endothelial cells in vivo and in vitro. J. Biomater. Sci. Polym. Ed., 20(1), 83-97 (2009).

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